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Clinical guide
Pragmatic prescribing to reduce harm for older people with moderate to severe frailty
Published date
Last updated
This document aims to support prescribing decisions for older people with moderate to severe frailty. This information can be incorporated into shared decision-making conversations. It provides more lenient therapeutic targets than standard guidelines, balancing potential benefits and harms of medicines in this population. The guidance is designed for all prescribers involved in medicines optimisation across primary and secondary care settings.
Endorsed by
This guidance has received formal endorsement from the following organisations:
Additionally, NICE has confirmed (November 2025) that this tool supports NICE guidance on multimorbidity (NG56), medicines adherence (CG76) and medicines optimisation (NG5) and that it is consistent with recommendations in relevant clinical guidelines.
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