Abstract
Abstract Content -
Introduction
Vitamin D is a fat-soluble vitamin essential for bone and muscle health through its role in regulating calcium and phosphate homeostasis. It exists in two main forms: vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). Approximately 90% of vitamin D is synthesized in the skin via exposure to ultraviolet B (UVB) radiation, with the remaining 10% obtained from dietary sources (Holick, 2007). Both forms are biologically inactive and must be enzymatically converted in the liver and kidneys to 1,25-dihydroxyvitamin D (1,25[OH]₂D) (DeLuca, 2004). In addition to musculoskeletal benefits, vitamin D supports immune regulation and wound healing (Gombart et al., 2020). Research indicates that deficiency increases vulnerability to infections and autoimmune diseases (Aranow, 2011).
Method of Audit
This audit aimed to assess clinical compliance with NICE guidelines in the management of vitamin D deficiency, which remains a significant public health concern. Data were collected from 258 adult inpatients diagnosed with vitamin D deficiency. We evaluated whether deficiencies were corrected appropriately, identified associated clinical features, and explored potential secondary causes.
Analysis and Results
Analysis revealed that patients aged 65 and older were at greater risk of vitamin D deficiency. Additionally, treatment compliance was poor, particularly in moderate to severe cases, where many patients did not receive the recommended dosage of 50,000 IU of vitamin D.
Conclusion
Vitamin D deficiency contributes to systemic inflammation and is linked to several chronic conditions (Pilz et al., 2016). Routine screening is recommended in patients presenting with vague or non-specific symptoms such as mood changes, fatigue, fever, chronic pain, or recurrent infections.
References
- Holick MF. (2007). N Engl J Med, 357(3), 266–281.
- DeLuca HF. (2004). Am J Clin Nutr, 80(6 Suppl), 1689S–1696S.
- Gombart AF, et al. (2020). Nutrients, 12(4), 988.
- Aranow C. (2011). J Investig Med, 59(6), 881–886.
- Pilz S, et al. (2016). Nat Rev Cardiol, 13(7), 404–417.
Comments
Vitamin D
Hello. Thank you for your poster. In recommendation, you say that people should have 50,000units of vitamin D a week for a 6 week course - why is this your chosen regime? Your conclusion also states that there is a lack of awareness about vitamin D deficiency - what change would you implement in order to improve that?