Areas for Improvement in the Treatment of Fall-Related Intracranial Bleeding in Older Adults
Abstract
Complications arising from head injuries obtained during falls, particularly intracranial bleeds (ICBs), are a major cause of morbidity and mortality in older
people. For older adults, the most common mechanism of injury leading to ICBs is falling, and up to 43% of those hospitalised for these fall-related bleeds
iexperience long-term disability. This audit set out to determine the effect of adherence to local and national guidelines for older people with fall-related ICBs.
We analysed clinical data pertaining to 84 people over the age of 65 (82.8 +- 8.50, 59.5% female) receiving care in the Royal Berkshire Hospital for post-fall
intracranial bleeding. The collected data included demographic information, medical and functional history, fall severity (graded by height), ICB type and
laterality, management (including time to CT, anticoagulation reversal, observations, and surgical input), and functional status at discharge. The primary
outcome was functional decline (care needs, mobility, and independence pre-admission compared to discharge). Secondary outcomes included rate of
complications and length of stay.
13.1% of people within our dataset died during their admission. 21.4% experienced a GCS drop during their admission and 19.0% experienced delirium. Other
common complications included pneumonia (9.5%), hyponatraemia (7.1%), AKI (6.0%), and seizures (4.8%). Upon comparison of treatment to local and
national guidelines, we observed two main areas for improvement: not enough people are transferred to major trauma centres (23%), and not enough people
receive a head CT within the recommended time frame (52%). Importantly, those that did not meet guidelines were more likely to have a reduction in
independence from pre-admission levels (relative risk 1.44, 95% CI [0.99, 2.08]).
These observations highlight specific areas for improvement in treatment of older adults with fall-related ICBs. They also suggest that increased adherence to
guidelines improves post-admission function of older adults after falls.
Comments
TXA
Hi Ella, your poster raises a number of pertinent questions in the network model. How do the team at Oxford feel about the "all patients with and ICB and GCS<8 should be transferred?" And how do you and your team feel. Transfer for supportive or EOL care at a location distant from family / support may not be in the best interests of the patient. The guideline relates to ICBs in all age groups - should it? I don't have the answers, and am trying to help work through them in Wessex. Many thanks. Bryan
Thank you Bryan, genuinely…
Thank you Bryan, genuinely. This is exactly the tension we sat with when we were interpreting our own findings, and I'm glad this poster has made it visible enough for someone to ask it aloud.
On the Oxford position: I have to be honest that we don't have a formal steer from the neurosurgical centre specifically in this age group. What I can tell you is that in all five of our GCS <8 patients, a neurosurgical discussion was held and documented via the Online Acute Referral System (OARS), and in none of those cases was transfer recommended. I'd be interested to hear how Oxford approach this in older frail patients, because that conversation would be useful for our next cycle. From what Dr Anthony Cox just said in the 10:30 talk, its sounds like these neurosurgical meetings tend to rule out patients on ground of frail pretty quickly.
On our own team's position: the data makes it hard for us to advocate for blanket transfer in this cohort. Two of our five patients were on a palliative pathway within days of admission. The other three had active goals-of-care conversations that shaped their management locally, with specialist input by phone. Transferring an 80 or 86 year old, away from their family, to receive supportive care that we can deliver with remote neurosurgical advice - it's a difficult ask to justify on patient-centred grounds, and our data doesn't give us a reason to think we got that wrong. I'd like to see the availability of a middle meningeal embolisation service for these conservatively managed patients.
On the guideline itself: I think you've put your finger on something important. NG232 is a guideline for intracranial bleeding across all age groups, and it wasn't written with the frail octogenarian falls patient primarily in mind. What it doesn't yet give us is clear guidance on the goals-of-care conversation that has to happen first in this population. Until it does, we'd argue that the more meaningful quality metric isn't whether transfer happened, but whether that specialist discussion was documented and informed the plan. That's what we've been capturing prospectively and will report on in the next cycle.
What we genuinely can't answer from this dataset is whether any of our non-transferred patients would have had a meaningfully better outcome with in-person specialist neurological care. That's a real question, and it's probably one that needs a network study to answer properly. If that's a conversation worth having at network level - we'd very much want to be part of it.
Dr Ella Dunlop F2 - Poster 4829
Nice work- question was ICB the only injury in these patients?
I work at a DGH too and transfer to neurosurgical centre is also a problem
Multiple Injury Data and Theory v. Practice in Transfers
Thank you - great question, and no, ICB was far from the only injury in many cases. Around half our patients had associated injuries documented — we had limb fractures in 10, skull fractures in 10, central or spinal injuries in 14, and soft tissue injuries in 11. There were some significant polytrauma cases in there - cervical spine fractures, haemopneumothorax, NOF fractures alongside the head injury. So the transfer question gets even more complicated when you factor in that some of these patients had injuries that needed managing locally regardless.
And yes - I suspect what you're describing is exactly what we see. The practical reality at a DGH is that the conversation with the neurosurgical centre happens, the advice is sensible and usually manage locally. However the friction around physical transfer — logistics, family, fitness for transfer, bed availability — means transfer rarely happens even when it theoretically should. It would be really interesting to know whether your experience mirrors ours on the GCS threshold question specifically.
On the TXA finding: A common question about missed oportunity
On the TXA finding: 56% of eligible patients didn't receive TXA — a common question I've had was were you able to drill down into why? Were these cases of clinician unfamiliarity with the GCS <12 threshold, late presentations where the window had passed, or undocumented contraindications? The root cause really changes what an intervention should look like. To answer this question - we don't have good understanding of why. My suspicion is that it is falling between the gaps in handover - is it a paramedic's role, ED doctors role, or the trauma team at the pre-alert who should initiate. The next step will be to survey these teams as part of figuring out what causes delay or missed TXA when it's part of NICE guidance. Feel free to ask me more!
TXA, Reversal Agents & Transfer to MTC
Nice poster. I currently work in the East Midlands MTC and we are unfortunately seeing a significant influx in the elderly patient on anticoags/platelets coming in bleeds. Firstly, is your DGH an MTU? Reason I ask is that being an MTU would mean having an SOP which triggers faster CT's resulting in better clincal outcomes bypassing the 8hr NICE guidelines. Secondly, the TXA administered to the patients in your poster, did they receive the TXA prehospital, in hospital, and did they receive 2g in total? Did any of the patients have any discussion with haematology regarding PCC reversal (although not a true reversal), and in your opinion, having ALL patients being transferred to an MTC seems like a resource mismanagement. Is there a reason why all patients who meet the mentioned criteria get transferred? Thanks.
Reply: TXA, Reversal Agents & Transfer to MTC
Thank you and yes, we're seeing exactly the same demographic pressure at Royal Berkshire, so this feels very familiar.
On the MTU question yes, the Royal Berkshire Hospital (Reading) is not a Trauma Unit within the Thames Valley Trauma Network, and the Major Trauma Centre for the region is the John Radcliffe Hospital in Oxford. Despite a local CT head SOP, we still find they often miss the window.
On TXA - there are limits to our data. We captured whether TXA was given at any time point during the patient journey including pre-hospitably, but we can't tell you from this dataset whether those patients received pre-hospital TXA, whether the full 2g was given, or the breakdown of timing. Thank you for highlighting the importance, and we can build it into the next cycle, so watch this space.
We did capture data on reversal, which didn't make it to the poster here. Of the 12 patients who received Beriplex, 7 were on a NOAC and 5 were on Warfarin, which suggests PCC reversal was happening in practice, all had a documented haematology discussion. Warfarin was reversed in all cases, however only a portion of the total patients on NOACs were reversed 12/19 admitted on a NOAC.
On transfer - I'd push back slightly on the framing. We're not advocating transferring all patients who meet criteria. The quote “Transfer would benefit anyone with a GCS <8 irrespective of the need for neurosurgery" is taken from the NICE guideline 232 1.8.1. It's an ambitious sentiment which we know is far from practice. Our finding is that specialist neurosurgical discussion happened in all appropriate GCS <8 cases, and in all cases the clinical decision was to manage locally with remote input. In a frail elderly cohort, transferring patients away from their families for supportive care that can be delivered locally with a phone call is very hard to justify. We're very much aligned with you on resource stewardship. I think we could make better use of local resources, with recognition that we often manage stroke at a high level in DGH, it feels like we have resources locally and just need clear local strategy. If MTCs would define in NICE guidance what TU "local management" could look like we can advocate for ourselves to be equipped the service resembling what we see in Stroke Units.
Correction: IS a Trauma Unit
Correct to the above - I should say "is a Trauma Unit*, instead of "is not a Trauma Unit". I re-framed it from "is not a MTC" without checking over.