Parkinson's Disease is one of the commonest neurological conditions to affect older people. The prevalence & incidence are both age related, with an overall prevalence in the general population of around 160 per 100,000 and an annual incidence of 13 per 100,000. Many population studies have shown the rising prevalence with age (up to around 2 per cent of the population aged 80 and over). Those surveys that fail to show the increase in the oldest groups are thought to be due to incomplete and show ascertainment bias (since the prevalence in residential and nursing homes is up to 10 per cent). It is a frequent cause of falls, fractures, and hospital admission. As such, it is a costly disease, especially in the later stages.
The costs of treatment (health and social care) have been estimated at between £560,000 and £1.6 million per 100,000 population (i.e. per 160 patients, or an annual cost of between £3,500 and £10,000 per person. Significant cost drivers include the onset of motor fluctuations, psychiatric symptoms, and institutional care [1,2,3].
Diagnosis of PD remains predominantly clinical. Diagnosis can be difficult and relies on the recognition of the cardinal features of bradykinesia, rigidity and tremor. This can be complicated in the elderly by the presence of co-morbidity such as dementia or cerebrovascular disease.
Diagnostic error is common with an error rate of up to 50 per cent in a community-based study . Accurate diagnosis is the cornerstone for predicting prognosis and planning of management. It is strongly recommended, therefore, that all patients with a suspected diagnosis of PD be referred for specialist assessment by an experienced clinician, ideally before treatment is started. The use of standard diagnostic criteria, such as the UK PDS Brain Bank has been shown to increase diagnostic accuracy (see appendix) .
The manner in which the diagnosis is communicated to patients and carers is very important and has been shown to have a significant effect on quality of life many years later . This should be carried out by an experienced clinician allowing adequate time and backed up with written information. It is good practice to arrange a second consultation to ensure that the information imparted has been understood and to allow further questions. The PD Nurse Specialist has a valuable role to play in this process.
Response to treatment is an important aspect when establishing the diagnosis. However, acute challenge tests using either oral levodopa or subcutaneous apomorphine are insufficiently sensitive or specific are not recommended for routine use .
C.T. brain scans show no abnormality in PD and are likewise not recommended routinely. In selected patients with an atypical presentation (e.g. prominent gait disorder, dementia) a C.T. scan may be of value in establishing an alternative diagnosis such as multiple cerebral infarcts or hydrocephalus. Laboratory testing will sometimes be appropriate - e.g. the exclusion of Wilson's disease or other more common confounding issues such as thyroid function and syphilis serology.
In cases of diagnostic uncertainty, access to functional imaging using FP-CIT SPECT scanning can be helpful in distinguishing parkinsonian from non-parkinsonian syndromes.
Although the earliest and more apparent effects of PD are on the motor system, non-motor problems are also very important in contributing to the overall impact of the condition. It is important, therefore, that assessment covers the physical, mental and social domains . Comprehensive assessment will necessarily be multidisciplinary. Physical assessment should include not only motor but sensory and autonomic function as well as the impact on activities of daily living, speech and swallowing. The mental domain should include assessment of cognitive function and mood as both dementia and depression are common. The social environmental domain includes assessment of quality of life.
A number of standardised assessment tools are available and their use is encouraged. Routine use of such tools allows 'hidden' problems to be identified and allows monitoring of progression. Standardised assessment also facilitates clinical audit. Appropriate tools include the Unified Parkinson's Disease Rating Scale (UPDRS) for motor assessment, Mini Mental State Examination (cognitive) , Geriatric Depression Scale (GDS15) and PDQ39 (quality of life). More specialised assessments are carried out by the relevant therapists as the need arises. The NMS Quest is a recently validated screening tool (accessed March 07) for the detection of non motor symptoms in PD.
Management of PD in elderly patients is made more challenging by the common occurrence of co-morbidity, both physical and psychiatric. This not only makes diagnosis more difficult but also presents management problems. Associated polypharmacy increases the potential for drug interactions and adverse effects. A full medical assessment is therefore essential. Specialists in Geriatric Medicine who are trained and experienced in managing complex problems in the elderly are well placed to carry out this function.
PD is a progressive condition and patients deteriorate gradually over time. This can be insidious with increasing impairment and handicap going unrecognised. Regular, planned follow-up by the specialist team is therefore advised.
Stage of disease can be classified according to the Hoehn & Yahr scale, which ranges from 1.0 (unilateral involvement only) to 5.0 (wheelchair bound or bedridden). This, however, concentrates on impairments rather than disability or handicap and is of limited use in the management of individual patients. A more useful paradigm has been developed which describes four stages in the evolution of the disease through diagnosis, maintenance, complex and palliative stages . The appropriate management at each of these stages is outwith the remit of this short paper, but described in the 'guideline papers' and the NICE clinical guideline referenced below [7,10,11].
As the disease progresses, dependency and psychiatric co-morbidity increase. In order to address the spectrum of need, a comprehensive service providing outpatient clinics, Day Hospital , inpatient assessment / rehabilitation and long term care is required.
Good Practice Statements
A number of 'guidelines' have been published, and are referenced below [7,10,11].
U.K. Specialist Guidelines  written primarily for the specialist practitioner.
Primary Care Guidelines  written primarily for the primary care team in the four stage structure .
American Algorithms  contain management issues and algorithms for common situations arising in PD - primarily for the specialist practitioner.
NICE have recently published a clinical guideline which is referenced under further reading.
Models of Service
In the U.K, the identified medical specialist may be a geriatrician or a neurologist. It is helpful if the two departments can work collaboratively, and will benefit from close working relationships with a PD Nurse Specialist and a dedicated Multi-disciplinary team . This will normally have elements of physiotherapy, occupational therapy, speech and language therapy, dietetics, and psychology. Exact relationships and location vary depending on the types of service configuration, management structures, rurality/population density, and transport availability. Some departments offer programmed multi-disciplinary sessions - often at diagnosis and at intervals thereafter. Others have open access or referral protocols, depending on local policies .
In addition to the components mentioned above, close working relationships are desirable with Neurosurgery, Psychiatry (including old age psychiatry), Psychology, and other disciplines.
Training / Education
Hitherto, knowledge of PD and movement disorders has been acquired in a rather indeterminate manner during general professional and higher specilaist training in geriatric medicine. With the increasing specialisation and subspecialisation of Modernising Medical Careers to the standards and competencies defined by PMETB this approach will become increasingly untenable. Experience in other specialties and sub-specialties suggest that some form of accreditation will become necessary if not a formal CCT in Movement Disorders. Reflecting this possible direction of travel the PD Academy was founded in 2002 and has run 9 formal Masterclasses for geriatricians who are keen to learn more about running a Service – 3 more have been recruited to and/or are planned. Similar courses are available for specialist nurses and other disciplines. Attendance at specialist meetings (Parkinson's Disease and Movement Disorders) is desirable as part of the portfolio of continuing professional development (CPD/CME).
1 MacMahon DG, Findley L, J Holmes, K Pugner on behalf of P Bain, M Baker, C Beech, C E Bowman, W Kingdom, V Peto, J Playfer. The True Economic Impact of Parkinson's disease: A Research Survey in the UK . Movement Disorders 2000; 15 (suppl. 3): P861: 178.
2 Jarman B. Hurwitz B. Cook A. Bajekal M. Lee A. Effects of community based nurses specialising in Parkinson's disease on health outcome and costs: randomised controlled trial. BMJ 2002; 324: 1072-5.
3 Thomas S, MacMahon DG, Henry S. Moving and Shaping. Parkinsons Disease Society, London 1999.
4 Meara J, Bhowmick BK, Hobson P. Accuracy of diagnosis in patients with presumed Parkinson's disease. Age and Ageing 1999; 28: 99-102.
5 Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181-4.
6 Findley LJ for Global Parkinson's Disease Steering Committee. Factors impacting on quality of life in Parkinson's disease: results from an international survey. Movement Disorders 2002;17:60-67.
7 Bhatia K, Brooks D, Burn D et al. Updated guidelines for the management of Parkinson's Disease. Hosp Med 2001;62(8): 456-70.
8 Meara RJ. Assessment. In: Playfer JR, Hindle JV (eds). Parkinson's Disease in the Older Patient. London : Arnold , 2001; 77-88.
9 Parkinson's Disease Society. Parkinson's Aware in Primary Care. A guide for primary care teams developed by the Primary Care Task Force for PDS (UK). Parkinsons Disease Society, London . 1999; 1-4.
10 Parkinson's Disease Task Force. PD Aware in Primary Care. PDS, London . 1999.
11 An Algorithm (Decision Tree) for the Management of Parkinson's Disease (2001). Olanow CW, Watts RL, Koller WC. Neurology 2001:56(supp5);S1-88.
12 MacMahon DG, Thomas S. Practical Approach to quality of life in Parkinson's disease: the nurse's role. J Neurol (1998) 245[suppl 1]: S19-22.
13 Iansek R. Interdisciplinary rehabilitation in Parkinson's disease. Adv Neurol 1999;80:555-9.
Parkinson's Disease in the Older Patient. Eds JR Playfer, JV Hindle. Arnold, London 2001 ISBN 0 340 75914 3.
Prodigy Guidance Parkinson’s Disease.
National Institute for Health and Clinical Excellence (NICE), Parkinson’s Disease Guidelines.
PD-UK PDS Brain Bank Diagnostic Criteria
Step 1 - Diagnosis of Parkinsonian syndrome
Bradykinesia plus at least one of the following…
Step 2 - Exclusion criteria including
History of repeated strokes
History of repeated head injury
History of definite encephalitis
Step 3 - Supportive prospective criteria (at least three required)
Rest tremor present
Evidence of progression
Excellent response to L-dopa
Severe L-dopa-induced chorea
L-dopa response for 5+ years
Clinical course of 10+ years